METHODS FOR THE TREATMENT AND DIAGNOSIS OF TYPE 1 DIABETES

摘要

The present invention relates to methods for the treatment and diagnosis of Type 1 Diabetes. In particular the present invention relates to a human preproinsulin peptide selected from the group consisting of: - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 1 to the amino acid residue at position 15 in SEQ ID NO:1 ("hPPI1-15") - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 16 to the amino acid residue at position 30 in SEQ ID NO:1("hPPI16-30") - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 20 to the amino acid residue at position 35 in SEQ ID NO:1("hPPI20-35") - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 25 to the amino acid residue at position 40 in SEQ ID NO:1("hPPI25-40") - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 80 to the amino acid residue at position 97 in SEQ ID NO:1("hPPI80-97") - a peptide consisting of 8 consecutive amino acids selected in the sequence ranging from the amino acid residue at position 92 to the amino acid residue at position 110 in SEQ ID NO:1("hPPI92-110").