发明名称 |
HUMAN MONOCLONAL AUTOANTIBODIES TO ADAMTS13 AND USES THEREOF |
摘要 |
The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP. |
申请公布号 |
WO2016164468(A2) |
申请公布日期 |
2016.10.13 |
申请号 |
WO2016US26224 |
申请日期 |
2016.04.06 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
SIEGEL, Donald L.;KACIR, Stephen;OSTERTAG, Eric;ZHENG, X. Long |
分类号 |
A61K49/00;A61K39/395 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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