| 摘要 |
<p>An agent for suppressing both progression and acute exacerbation of decreased respiratory function with age in respiratory disease, comprising a compound having a squalene synthase inhibitory action and represented by the formula: (I) (wherein R<SUB>1</SUB> represents a hydrogen atom or a hydrocarbon group which may be substituted; R<SUB>2</SUB> and R<SUB>3</SUB> are the same or different and represent a hydrogen atom, a hydrocarbon group which may be substituted or the like; X' represents a carboxyl group which may be esterified, a carbamoyl group which may be substituted, a hydroxy group which may be substituted, an amino group which may be substituted, or a group constituted by a heterocyclic residue which has a deprotonatable hydrogen atom and may be substituted; the ring A represents a benzene ring or a heterocyclic ring which may be substituted; the ring J' represents a 7- or 8-membered heterocyclic ring containing 3 or less heteroatoms as ring constituent atoms, and the ring J' may further have a substituent other than R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB> and X').</p> |
