摘要 |
The present invention provides methods for the detection of RNA in a sample, comprising (a) mixing a specific amount of a rod-shaped virus-like particle with a sample, wherein the rod-shaped virus-like particle comprises a ribonucleic acid molecule and a viral coat, wherein: (i) the ribonucleic acid molecule comprises an origin-of-assembly sequence of a rod-shaped RNA virus and a heterologous sequence; and (ii) the viral coat comprises at least one type of coat protein of the rod-shaped RNA virus; (b) isolating RNA from the sample; and (c) detecting RNA comprising the heterologous sequence. |