发明名称 |
Antagonistisk anti-CD40-antistofmutant. |
摘要 |
A mutant of a potentially therapeutic anti-CD40 antibody is provided which mutant has reduced ADCC and CDC activities designed to be optimized as a pharmaceutical agent. A mutant of an agonistic anti-CD40 antibody, comprising mutation and/or substitution of at least one amino acid in the constant region to reduce the ADCC and/or CDC activities therein, and a mutant of an antagonistic anti-CD40 antibody, comprising at least one mutation or substitution in the constant region to reduce the ADCC and/or CDC activities therein, both mutants having at least a hinge region derived from a human IgG2. |
申请公布号 |
DK1707627(T3) |
申请公布日期 |
2012.12.17 |
申请号 |
DK20040808100T |
申请日期 |
2004.12.24 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
TAKAHASHI, NOBUAKI;MIURA, TORU;KITAGAWA, YOSHINORI;HIRANO, AKI |
分类号 |
C12N15/09;A61K39/395;A61P37/00;C07K16/28;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|