BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES

摘要

Provided herein are methods of utilizing bile acid transport inhibitors for the treatment of obesity and diabetes.

主权项

1. A therapeutic method comprising
a) reducing food intake in an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI); b) inducing satiety in an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); c) reducing blood and/or plasma glucose levels in an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); d) treating a metabolic disorder in an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); e) reducing the weight of an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); f) stimulating L-cells in the distal gastrointestinal tract of an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); g) increasing the concentration of bile acids and salts thereof in the vicinity of L-cells in the distal gastrointestinal tract of an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); h) enhancing enteroendocrine peptide secretion in an individual in need thereof comprising contacting the distal ileum of the individual with an Apical Sodium-dependent Bile Acid Transporter inhibitor (ASBTI); or i) any combination thereof.