ANDROGEN RECEPTOR MODULATOR AND USES THEREOF

摘要

Described herein is the androgen receptor modulator of formula (I);;in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.

主权项

1. A method of treating metastatic castration-resistant prostate cancer, non-metastatic castration-resistant prostate cancer, metastatic castration-sensitive prostate cancer, non-metastatic castration-sensitive prostate cancer or high-risk localized prostate cancer in a male human patient comprising orally administering the compound of Formula (I), or a pharmaceutically acceptable salt thereof,to a human male patient in need of such treatment at a dose of about 30 mg per day to about 480 mg per day, in combination with:
(a) abiraterone acetate (Zytiga); (b) Ipilimumab; (c) everolimus; (d) leuprolide or leuprolide acetate (Lupron or Eligard); or (e) goserelin acetate (Zoladex).