| 发明名称 |
CYCLOPROPYLAMINES AS LSD1 INHIBITORS |
| 摘要 |
This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer. |
| 申请公布号 |
US2016220547(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201615095280 |
申请日期 |
2016.04.11 |
| 申请人 |
GlaxoSmithKline Intellectual Property (No.2) Limited |
发明人 |
JOHNSON Neil W.;Kasparec Jiri |
| 分类号 |
A61K31/445 |
主分类号 |
A61K31/445 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer which comprises administering to a human in need thereof an effective amount of a compound which is 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid, represented by the formula:or a pharmaceutically acceptable salt thereof. |
| 地址 |
Brentford GB |
