TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE IMMUNE RESPONSES TO THERAPEUTIC PROTEINS

摘要

Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.

主权项

1. A composition having a special physical form, wherein:
(i) said special physical form comprises synthetic nanocarrier particulates; (ii) said synthetic particulates comprise a PLGA polymer; (iii) a first population of said synthetic particulates are coupled to immunosuppressants; and (iv) a second population of said synthetic particulates are coupled to therapeutic protein APC presentable antigens wherein a mean of a particle size distribution obtained using dynamic light scattering of the synthetic nanocarrier particulates of the first and/or second population is a diameter greater than 100 nm.