RECOMBINANT AAV VECTORS WITH AAV5 CAPSIDS AND AAV5 VECTORS PSEUDOTYPED IN HETEROLOGOUS CAPSIDS
摘要
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any cross-reactive serotype of the AAV ITRS are utilized. A similar method may be provided to generate a pseudotyped rAAV in which minigenes carrying AAV5 ITRs are packaged in capsids of a heterologous AAV serotype. Also provided are pharmaceutical compositions containing the pseudotyped rAAV and methods of using them for gene delivery.
申请公布号
WO0183692(A2)
申请公布日期
2001.11.08
申请号
WO2001US13000
申请日期
2001.04.23
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;HILDINGER, MARKUS;WILSON, JAMES, M.;AURICCHIO, ALBERTO
发明人
HILDINGER, MARKUS;WILSON, JAMES, M.;AURICCHIO, ALBERTO