PROTAMINE PEPTIDOMIMETIC, AND PHARMACEUTICALLY ACCEPTABLE SALTS AND USE THEREOF

摘要

The present invention discloses a protamine-like peptide and the pharmaceutical salt and use thereof. The protamine-like peptide is a linear polypeptide consisting of 9 to 20 basic amino acid residues, and the basic amino acid is one or more kinds selected from the group consisting of Arginine (Arg, R), Lysine (Lys, K) and Histidine (His, H). It has been proved that the series of protamine-like peptides and the pharmaceutical salts thereof function as the protamine to neutralize and antagonize heparin in the blood. Therefore, they can be used clinically in stead of the protamine to eliminate and neutralize the bleeding tendency caused by heparin in the blood.