发明名称 |
METHOD FOR PRODUCING (BROMOMETHYL)CYCLOPROPANE AND (BROMOMETHYL)CYCLOBUTANE |
摘要 |
The present invention relates to a method for obtaining high purity (bromomethyl)cyclopropane and (bromomethyl)cyclobutane, starting respectively with cyclopropylmethanol and cyclobutylmethanol, under synthesis conditions that enable high productivity and high yield. |
申请公布号 |
US2016355452(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
US201415109925 |
申请日期 |
2014.12.01 |
申请人 |
MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE |
发明人 |
GUERRET Olivier |
分类号 |
C07C17/16 |
主分类号 |
C07C17/16 |
代理机构 |
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代理人 |
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主权项 |
1. Method for preparing a compound (A) of the following formula: in which R is a cyclobutane or cyclopropane group, comprising the following steps:
a) solubilizing a triarylphosphite in a polar aprotic solvent,b) adding a bromine compound at a temperature of less than 15° C.,c) lowering the temperature to less than 0° C. after completion of the reaction of the bromine with the triarylphosphite,d) adding cyclobutylmethanol or cyclopropylmethanol at a temperature of less than 0° C.,e) recovering the compound (A). |
地址 |
Lacq FR |