发明名称 |
PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-SUBSTITUTED CARBOXYLIC ACID |
摘要 |
<p>The present invention relates to a process for efficiently producing an optically active 2-bromocarboxylic acid and an optically active 2-sulfonyloxycarboxylic acid, which are important in the production of medicinal compounds and so forth. <??>An optically active 2-sulfonyloxycarboxylic acid ester is subjected to deprotection under acid conditions to obtain an optically active 2-sulfonyloxycarboxylic acid. A metal bromide is caused to act on the acid to brominate it with configuration inversion at position 2 to thereby produce an optically active 2-bromocarboxylic acid. The resultant optically active 2-bromocarboxylic acid is isolated/purified by subjecting it to a step in which the acid is crystallized and separated as a salt with a base. Thus, an optically active 2-bromocarboxylic acid having a high chemical purity and high optical purity can be produced.</p> |
申请公布号 |
EP1422215(A4) |
申请公布日期 |
2005.07.06 |
申请号 |
EP20020755871 |
申请日期 |
2002.08.08 |
申请人 |
KANEKA CORPORATION |
发明人 |
YAMASHITA, KOKI;TAKEDA, TOSHIHIRO;KINOSHITA, KOICHI;UEDA, YASUYOSHI |
分类号 |
C07C51/363;C07C51/43;C07C51/48;C07C57/58;C07C67/52;C07C67/58;C07C303/28;C07C303/30;C07C309/66;(IPC1-7):C07C51/363;C07C69/675;C07C53/19;C07C309/70;C07B55/00;C07C69/732;C07C67/08 |
主分类号 |
C07C51/363 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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