发明名称 |
MUTAGENIC NUCLEOSIDE ANALOGS AND USES THEREOF |
摘要 |
The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs may show multiple tautomerism and may increase the mutation of an RNA and/or DNA (be mutagenic) of a virus or cancer cell. The multiple tautomerism and mutagenesis of the nucleoside analogs may be adjusted by substituting the nucleoside analogs with one or more electron-donating groups and/or electron-withdrawing groups to increase or decrease the pK a (e.g., to a pK a between 5.5 or 8.5). The present disclosure also provides pharmaceutical compositions and kits including the nucleoside analogs and methods of treating a viral infection (e.g., influenza, HIV infection, or hepatitis) or cancer using the nucleoside analogs, pharmaceutical compositions, or kits. |
申请公布号 |
WO2016123397(A2) |
申请公布日期 |
2016.08.04 |
申请号 |
WO2016US15456 |
申请日期 |
2016.01.28 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
ESSIGMANN, JOHN, M.;TOKMAKOFF, ANDREI;FEDELES, BOGDAN, I.;SINGH, VIPENDER;PENG, CHUNTE |
分类号 |
C07H19/173;A61K31/7052;A61K31/706;A61K31/7076;A61K31/708;A61P31/12;A61P31/18;A61P31/20;A61P35/00;C07H19/04;C07H19/23 |
主分类号 |
C07H19/173 |
代理机构 |
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代理人 |
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地址 |
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