发明名称 |
High affinity HIV T cell receptors |
摘要 |
The present invention provides TCRs having an affinity (K D ) of less than or equal to 1µM, and/or an off-rate (k off ) of 1x10 -3 S -1 or slower, for the SLYNTVATL-HLA-A*0201 complex PROVIDED THAT when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex. |
申请公布号 |
EP2275441(B8) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20100008612 |
申请日期 |
2006.03.29 |
申请人 |
IMMUNOCORE LTD.;ADAPTIMMUNE LIMITED |
发明人 |
JAKOBSEN, BENT KARSTEN;MOLLOY, PETER EAMON;LI, YI;DUNN, STEVEN MARK |
分类号 |
C07K14/725;A61K38/17;A61P31/18;A61P37/04;C12N15/12 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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