| 发明名称 |
METHOD AND MARKERS FOR ASSESSING THE RISK OF HAVING COLORECTAL CANCER |
| 摘要 |
The disclosure discloses a method and markers for assessing the risk of having colorectal cancer by a blood sample obtained from an individual. The assessment method includes the steps of: detecting expression levels of a first microRNA and a second microRNA in the blood sample; and assessing the risk of having colorectal cancer for the individual based on a ratio between the expression levels of the first microRNA and the second microRNA. Here, the first microRNA is miR-221, miR-92a, miR-15a, miR-24, miR-18a, miR-191, miR-128, or miR-223, and the second microRNA is miR-10b, miR-100, miR-29a, miR-126, miR-139, miR-31, miR-145, or miR-155. When the first microRNA is miR-128, the second microRNA is miR-10b, miR-100, miR-29a, miR-126, miR-139, miR-31, or miR-145. |
| 申请公布号 |
US2016201139(A1) |
申请公布日期 |
2016.07.14 |
| 申请号 |
US201514928625 |
申请日期 |
2015.10.30 |
| 申请人 |
Chang Gung University ;Chang Gung Memorial Hospital, Linkou |
发明人 |
CHEN Jinn- Shiun;CHANG Yu-Sun;CHAN Err-Cheng;CHEN Chia-Chun;CHANG Pi-Yueh |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A method for assessing the risk of having colorectal cancer for an individual by a blood sample obtained from the individual, comprising:
detecting expression levels of a first microRNA and a second microRNA in the blood sample; and assessing the risk of having colorectal cancer for the individual based on a ratio between the expression levels of the first microRNA and the second microRNA; wherein the first microRNA is selected from the group consisting of miR-221, miR-92a, miR-15a, miR-24, miR-18a, miR-191, miR-128, and miR-223, the second microRNA is selected from the group consisting of miR-10b, miR-100, miR-29a, miR-126, miR-139, miR-31, miR-145, and miR-155, and when the first microRNA is miR-128, the second microRNA is miR-10b, miR-100, miR-29a, miR-126, miR-139, miR-31, or miR-145. |
| 地址 |
Taoyuan City TW |
