An ex vivo method of predicting toxicity to tyrosine kinase inhibitors

摘要

594178 Provided is an ex vivo method for predicting toxicity in response to treatment with a tyrosine kinase inhibitor drug, said method comprising, identifying whether a cell oxidizes fatty acids in response to treatment with a drug, wherein the drug is predicted to be toxic to the cell where the cell is identified to not oxidize fatty acids in response to treatment with the drug or wherein the drug is predicted to not be toxic to the cell where the cell is identified to oxidize fatty acids in response to treatment with the drug.