METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS

摘要

Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.

主权项

1. A method of treating abnormal involuntary movement in a subject, comprising:
a) administering to the subject an initial daily amount of deutetrabenazine of at least about 6 mg/day; b) determining the degree of control of abnormal involuntary movement achieved with the initial daily amount and the tolerability of the initial daily amount after about one week; c) increasing the daily amount of the deutetrabenazine by at least about 6 mg/day to a first subsequent daily amount if the abnormal involuntary movement is not reduced and the initial daily amount is tolerable; d) optionally, repeating steps b) and c) after about one week until abnormal involuntary movement is reduced and the first subsequent daily amount of the deutetrabenazine is tolerable; and e) decreasing the daily amount by at least about 6 mg/day to a second subsequent daily amount if said first subsequent daily amount is not tolerated.