| 发明名称 |
PROCESS FOR THE MANUFACTURE OF CYCLIC UNDECAPEPTIDES |
| 摘要 |
The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir. |
| 申请公布号 |
US2016304554(A1) |
申请公布日期 |
2016.10.20 |
| 申请号 |
US201615198152 |
申请日期 |
2016.06.30 |
| 申请人 |
GALLOU Fabrice;RISS Bernard |
发明人 |
GALLOU Fabrice;RISS Bernard |
| 分类号 |
C07K1/12;C07K7/06;C07K7/64;C07K1/107 |
主分类号 |
C07K1/12 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A process for preparing a compound of formula 3 or a salt thereof, wherein R is methyl, ethyl, propyl or phenyl and R′ is methyl or ethyl, the method comprising the steps of acylation of cyclosporin A, to form acetyl-Cyclosporin A; ring opening of the acetyl-Cyclosporin A; and crystallizing the ring opened acetyl-Cyclosporin A to obtain a compound of formula 3. |
| 地址 |
Basel CH |
