| 主权项 |
1. A compound of formula or a pharmaceutically acceptable salt thereof, wherein L is a bond, —[C(R1)2]m—, -cyclopropyl-, or —CO—; m is 1 or 2; n is 0, 1, 2, 3, or 4; R1 is independently selected from H, C1-3alkyl, C1-3haloalkyl, —OH, or halo; A is phenyl, cyclohexyl, a 5 or 6 membered heterocyclyl, or a 5 or 6 membered heteroaryl, wherein the phenyl is optionally fused to a 5 or 6 membered heterocyclyl or 5 or 6 membered heteroaryl, wherein A is optionally substituted with 1, 2, or 3 RA groups, wherein
each RA is independently RA1, —C1-C6alkyl-RA1, C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, or heterocyclyl wherein the cycloalkyl and heterocyclyl are each optionally substituted with 1, 2, 3, or 4 groups that are independently RA1, C1-C6alkyl, or —C1-C6alkyl-RA1, wherein
each RA1 is independently halogen, cyano, nitro, —OR, —NR2, —SR, —C(O)R, or —C(O)OR;alternatively, 2RA on adjacent carbons can join to form a —O—CH2—O—, —O—CH2— CH2—, —O—CH2—CH2—O—, —CH2—CH2—CH2—, or —O—CF2—O—; ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with C1-4alkyl, C2-3alkenyl, C1-3haloalkyl, C3-6cycloalkyl, —CF3, —C1-4alkyl-OH, —C1-4alkyl-O—C1-3alkyl, —C1-3alkyl-NR2; —C1-3alkyl-CO2H, —C1-3alkyl-NHSO2—C1-3alkyl, —NH—C1-3alkyl-OR, —C1-3alkyl-pyrrolidinyl; RB1 is hydrogen, C1-3alkyl, halo, or C1-3haloalkyl; RB2 is hydrogen or halo; RB3 is hydrogen, C1-3alkyl, halo, —CN, C1-3haloalkyl, —C(O)—C1-3alkyl, —CO—NH2, —CO—N(R)2, or —C1-3alkyl-OH, each RD1 and RD2 are independently RD3, C1-C6alkyl, —C1-C6alkyl-RD3, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, or heterocyclyl, wherein the cycloalkyl or heterocyclyl are each optionally substituted with 1, 2, 3, or 4 groups that are independently RD3, C1-C6alkyl, C3-C6cycloalkyl, or —C1-C6alkyl-RD3, wherein
each RD3 is independently halogen, cyano, —OR, —NR2, —SR, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)R, —S(O)2R, —S(O)NR2, —S(O)2NR2, —OC(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)NR2, —N(R)S(O)2R, —N(R)S(O)2OR, —N(R)S(O)2NR2, or —S(O)2N(R)C(O)NR2; and RC is hydrogen, halogen, C1-C6alkyl, cyano, or nitro; each R group is independently hydrogen, C1-C6alkyl, —C1-C6alkyl-R2, C1-C6haloalkyl, —C1-C6haloalkyl-R2, C2-C6alkenyl, C2-C6alkynyl, or C3-C8cycloalkyl, wherein
each R2 is independently cyano, —OR3, —N(R3)2, —N(R3)S(O)2R3, —N(R3)S(O)2OR3, or —N(R3)S(O)2N(R3)2, wherein each R3 is independently hydrogen, C1-C6alkyl, or C1-C6haloalkyl. |
