| 发明名称 |
ANIMAL MODEL OF NASH-INDUCED HEPATOCELLULAR CARCINOMA AND METHODS FOR DEVELOPING SPECIFIC THERAPEUTICS |
| 摘要 |
The invention provides a non-human animal model for non-alcoholic steatohepatitis (NASH)-induced heptocellular carcinoma, methods of screening for agents for treating heptocellular carcinoma, methods of screening for targets useful in suppressing NASH progression to heptocellular carcinoma, methods of treating heptocellular carcinoma, and compositions for treating the same. |
| 申请公布号 |
US2016360735(A1) |
申请公布日期 |
2016.12.15 |
| 申请号 |
US201615178935 |
申请日期 |
2016.06.10 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Karin Michael;Umemura Atsushi;Nakagawa Hayato |
| 分类号 |
A01K67/027;G01N33/50;C12Q1/68 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inducing hepatocellular carcinoma (HCC) or HCC-like symptoms in a non-human animal comprising transplanting HCC progenitor cells (HcPCs) into a non-human animal and subjecting the mammal to a high fat diet (HFD). |
| 地址 |
Oakland CA US |
