发明名称 |
T CELL RECEPTOR-LIKE ANTIBODY AGENTS SPECIFIC FOR EBV LATENT MEMBRANE PROTEIN 2A PEPTIDE PRESENTED BY HUMAN HLA |
摘要 |
Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma. |
申请公布号 |
WO2016201124(A2) |
申请公布日期 |
2016.12.15 |
申请号 |
WO2016US36735 |
申请日期 |
2016.06.09 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER;EUREKA THERAPEUTICS, INC. |
发明人 |
CHEUNG, Nai-Kong V.;AHMED, Mahiuddin;LOPEZ-ALBAITERO, Andres;LIU, Cheng;LIU, Hong;XIANG, Jingyi;YAN, Su |
分类号 |
A61K39/42;C07K16/08 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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地址 |
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