Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are the 2-deoxystreptamine (2-DOS) aminoglycosides. Disclosed herein are members of the 2-DOS class that are useful for the inhibition of binding of an RNA to a trans-activating protein.
申请公布号
WO9409792(A1)
申请公布日期
1994.05.11
申请号
WO1993US10183
申请日期
1993.10.25
申请人
UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER;GREEN, MICHAEL, R.;ZAPP, MARIA, L.;STERN, SETH