Polymeric drug release system for medical devices

摘要

A coating composition comprising a mixture of a poly(vinylacetal-co-vinylalcohol-co-vinylacetate) and a poly(vinylpyrrolidone-co-vinylacetate) allows a medical device to be coated with a first layer containing a first bioactive material (such as rapamycin) and a second layer containing a second bioactive material (such as dexamethasone) for release in vivo at different release rates.