发明名称 |
Chimeric HCN channels |
摘要 |
This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.
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申请公布号 |
US2007099268(A1) |
申请公布日期 |
2007.05.03 |
申请号 |
US20060519399 |
申请日期 |
2006.09.11 |
申请人 |
COHEN IRA S;ROSEN MICHAEL R;BRINK PETER R;ROBINSON RICHARD B |
发明人 |
COHEN IRA S.;ROSEN MICHAEL R.;BRINK PETER R.;ROBINSON RICHARD B. |
分类号 |
C07K14/705;C07H21/04;C12P21/06 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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