发明名称 MEDICAL USE OF SELECTIVE ESTROGEN RECEPTOR MODULATOR IN COMBINATION WITH SEX STEROID PRECURSOR
摘要 <P>PROBLEM TO BE SOLVED: To provide novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans. <P>SOLUTION: The methods involve administration of selective estrogen receptor modulator, particularly ones having a structure of general formula (I) and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3&beta;,17&beta;-diol and compounds converted in vivo to one of the foregoing precursor. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013049703(A) 申请公布日期 2013.03.14
申请号 JP20120248384 申请日期 2012.11.12
申请人 ENDORECHERCHE INC 发明人 LABRIE FERNAND
分类号 A61K31/5685;C07D333/56;A61K31/133;A61K31/381;A61K31/40;A61K31/4025;A61K31/403;A61K31/404;A61K31/4436;A61K31/4453;A61K31/453;A61K31/475;A61K31/56;A61K31/565;A61K31/568;A61K31/57;A61K31/66;A61K45/00;A61K45/06;A61P3/06;A61P9/10;A61P15/00;A61P15/02;A61P19/10;A61P21/00;A61P35/00;A61P43/00;C07D209/10;C07D311/60 主分类号 A61K31/5685
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