| 发明名称 |
MULTIPLE-CONTROL CALIBRATORS FOR DNA QUANTITATION |
| 摘要 |
The present invention provides DNA plasmids that find use as calibrators or reference standards for calculating DNA quantities in a sample. In particular, provided herein are DNA plasmids that contain multiple control fragments, and methods of their use in DNA quantitation. |
| 申请公布号 |
US2016273030(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201415033803 |
申请日期 |
2014.11.04 |
| 申请人 |
EXACT SCIENCES CORPORATION |
发明人 |
Domanico Michael;Tyler Ilse A.;Aizenstein Brian;Allawi Hatim;Lidgard Graham P. |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A calibrator DNA comprising:
(a) A vector portion, and (b) A control portion; wherein the control portion comprises two or more serially-linked control fragments separated by restriction endonuclease recognition sites, wherein the vector portion circularizes the calibrator DNA by flanking both ends of the control portion, and wherein the vector portion and the control portion are separated by restriction endonuclease sites. |
| 地址 |
Madison WI US |
