Humanized antibodies, capable of specific binding to human CEACAMl molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.
申请公布号
AU2015254886(A1)
申请公布日期
2016.11.03
申请号
AU20150254886
申请日期
2015.04.27
申请人
CCAM Biotherapeutics Ltd.
发明人
Ben-Moshe, Tehila;Sapir, Yair;Mandel, Ilana;Markel, Gal;Schachter, Jacob;Ortenberg, Rona;Carr, Francis Joseph;Holgate, Robert George E.;Jones, Timothy David
