| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/126746 A3 29 August 2013 (29.08.2013) W I PO I P CT (51) International Patent Classification: CA 94103 (US). SHAO, Hui; 815 Peary Lane, Foster City, C07K 16/28 (2006.01) C07K 14/47 (2006.01) CA 94404 (US). AK47/48 (2006.01) A61P35100 (2006.01) (74) Agents: GARRETT, Arthur, S. et al.; Finnegan, Hender son, Farabow, Garrett & Dunner, LLP, 901 New York Av (21) International Application Number: enue, NW, Washington, DC 20001-4313 (US). PCT/US2013/027391 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 22 February 2013 (22.02.2013) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (30) Priority Data: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 61/603,173 24 February 2012 (24.02.2012) US NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 61/719,803 29 October 2012 (29.10.2012) US RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (71) Applicant: STEM CENTRX, INC. [US/US]; 450 East TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, Jamie Court, South San Francisco, CA 94080 (US). ZM, ZW. (72) Inventors: STULL, Robert, A.; 1519 Fifth Street, (84) Designated States (unless otherwise indicated, for every Alameda, CA 94501 (US). SAUNDERS, Laura; 170 King kind of regional protection available): ARIPO (BW, GH, Street, Unit 809, San Francisco, CA 94107 (US). DYLLA, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, Scott, J.; 743 Wake Forest Drive, Mountain View, CA UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 94043 (US). FOORD, Orit; 712 Cayman Lane, Foster TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, City, CA 94404 (US). LIU, David; 300 Santa Rosa Aven- EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, ue, Apt. 1, San Francisco, CA 94112 (US). TORGOV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, M 1 StreetAApt..1522, San FranciscoCA94112(US).TRG , TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, -Michael; 1188 Mission Street, Apt. 1522, San Francisco, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: DLL3 MODULATORS AND METHODS OF USE Biochemical Characteristics of Selected DLL3 Modulators - ~~~~SCIlO E .F2 4U 1 D SCN671 D EGC 2 O 31 Yo' No S Bacore; G ForteBio; Yeast Display (57) Abstract: Modulators of DLL3, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided. W O 2013/126746 A3 |lll|llll||||| ||||||||||||||| |||||||I||||||||I||||||||| Published: - with sequence listing part of description (Rule 5.2(a)) - with international search report (Art. 21(3)) (88) Date of publication of the international search report: - before the expiration of the time limit for amending the 20 March 2014 claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) |
