| 主权项 |
1. A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, or a glucuronide derivative thereof, or a co-crystal thereof,wherein
Y represents C3-7 cycloalkyl, aryl, C3-7 heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more substituents; Z represents a heteroatom, carbonyl; —S(O)—, —S(O)2—, —S(O)(N—Rd), —NC(O)Rd, —N(CO)—ORd, —NS(O)2Rd, or —N(Rd); or an optionally substituted straight or branched C1-4 alkylene chain; R1 and R2 independently represent hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy, —ORa, —SRa, —SORa, —SO2Ra, —SF5, —NRcCORd, —NRcCO2Rd, —NHCONRbRc, —NRcSO2Re, —N(SO2Re)2, —NHSO2NRbRc, —CORd, —CO2Rd, —CONRbRc, —CON(ORa)Rb, —SO2NRbRc, or —S(O)(N—Rd)Ra; or C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, C3-7 heterocycloalkenyl, C4-9 heterobicycloalkyl, heteroaryl, heteroaryl(C1-6)alkyl, (C3-7)heterocycloalkyl(C1-6)alkyl-aryl-, heteroaryl(C3-7)heterocycloalkyl-, (C3-7)cycloalkyl-heteroaryl-, (C3-7)cycloalkyl(C1-6)alkyl-heteroaryl-, (C4-7)cycloalkenyl-heteroaryl-, (C4-9)bicycloalkyl-heteroaryl-, (C4-9)bicycloalkenyl-heteroaryl-, (C3-7)heterocycloalkyl-heteroaryl-, (C3-7)heterocycloalkyl(C1-6)alkyl-heteroaryl-, (C3-7)heterocycloalkenyl-heteroaryl-, (C4-9)heterobicycloalkyl-heteroaryl- or (C4-9)spiroheterocycloalkyl-heteroaryl-, any of which groups may be optionally substituted by one or more substituents; R3 and R4 independently represents hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy or —ORa; or C1-6 alkyl optionally substituted by one or more substituents; and R5a and R5b independently represent hydrogen, hydroxy, halogen, trifluoromethyl, cyano; or —NRbRc, —NRcC(O)Rd, —(CO)NRcRd, —NHS(O)2Re, —S—Ra, —(SO)—Ra, —S(O)2Ra, —S(O)(N—Rd), —S(O)2(N—Rd), —ORa, —C(O)—ORd, —O(CO)—Rd—; C1-6 alkyl, C2-6 alkynyl, heteroaryl, any of which groups may be optionally substituted by one or more substituents; or R5a and R5b when taken together with the carbon to which they are attached represent a carbonyl, thiocarbonyl or —C═N—OH; and R6 represents hydrogen, hydroxy, halogen, trifluoromethyl, cyano; or —NRbRc, —NRcC(O)Rd, —(CO)NRcRd, —NHS(O)2Re, —S—Rd, —(SO)—Ra, —S(O)2Ra, —S(O)(N—Rd), —S(O)2(N—Rd), —ORa, —C(O)—ORd, —O(CO)—Rd—; C1-6 alkyl, C2-6 alkynyl, heteroaryl, any of which groups may be optionally substituted by one or more substituents; or R6 and Y together with the carbon to which they are attached form a C3-7 cycloalkyl or C3-7 heterocycloalkyl, optionally substituted with one or more substituents; and Ra represents C1-6 alkyl, aryl, aryl(C1-6)alkyl, C3-7 cycloalkyl, C3-7 heterocycloalkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents; Rb and Rc independently represent hydrogen or trifluoromethyl; or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents; or Rb and Rc, when taken together with the nitrogen atom to which they are both attached, represent azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl, homopiperazin-1-yl, (imino)(oxo)thiazinan-4-yl, (oxo)thiazinan-4-yl or (dioxo)thiazinan-4-yl, any of which groups may be optionally substituted by one or more substituents; Rd represents hydrogen; or C1-6 alkyl, C3-7 cycloalkyl, aryl, C3-7 heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more substituents; and Re represents C1-6 alkyl, aryl or heteroaryl, any of which groups is optionally substituted by one or more substituents. |
