| 主权项 |
1. A compound of formula (I):wherein:
X is CH or N; Y is CH or N; A is selected from the group consisting of: -A′-B′—, A′ is selected from the group consisting of: B′ is phenyl, a 5-membered heteroaryl, or a 6-membered heteroaryl, wherein A′ and C are attached to B′ in a meta-orientation, and the phenyl, 5-membered heteroaryl, and 6-membered heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, deuterium, methyl, trifluoromethyl, methoxy, and trifluoromethoxy; C is selected from the group consisting of: D is selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C15)carbocycle, aryl, and heteroaryl, wherein the (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C15)carbocycle, aryl, and heteroaryl, are optionally substituted with one or more groups Rz independently selected from halo, deuterium, nitro, hydroxy, cyano, carboxy, —NRaRb, —C(═O)NRaRb, —N—S(O)2Ra, —NRaC(═O)NRaRb, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, (C3-C15)carbocycle, aryl, aryloxy, and heteroaryl, wherein any (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, (C3-C15)carbocycle, and (C1-C4)alkanoyloxy of Rz is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, deuterium, —NRaRb, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, aryl, aryloxy, and heteroaryl, wherein any aryl, aryloxy, and heteroaryl of Rz is optionally substituted with one or more groups independently selected from the group consisting of halo, deuterium, halo, nitro, cyano, hydroxy, —NRaRb, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, (C1-C4)haloalkyl, Rx, and (C1-C4)haloalkoxy; each Ra and Rb is independently selected from the group consisting of H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, aryl, and heteroaryl, wherein any (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, and (C1-C4)alkanoyloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, deuterium, hydroxy, (C3-C15)carbocycle, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, oxo (═O), aryl, and heteroaryl, and wherein any aryl and heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, deuterium, nitro, cyano, carboxy, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C15)carbocycle, —NRcRd, —C(═O)NRcRd, (C1-C4)alkoxycarbonyl, (C1-C4)haloalkyl, aryl, heteroaryl, and ReO—; or Ra and Rb together with the nitrogen to which they are attached form an azetidinyl, morpholino, piperazino, pyrrolidino or piperidino, wherein any a azetidinyl, morpholino, piperazino, pyrrolidino, 1,1-(dioxido)thiomorpholino and piperidino is optionally substituted with one or more groups independently selected from halo, oxo, and (C1-C4)alkyl; each Rc and Rd is independently selected from the group consisting of H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, and (C1-C4)alkoxy, wherein any (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkanoyl, (C1-C4)alkoxycarbonyl, and (C1-C4)alkanoyloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, deuterium, (C3-C15)carbocycle, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, (C1-C4)alkanoyloxy, and oxo (═O); or Rc and Rd together with the nitrogen to which they are attached form a morpholino, piperazino, pyrrolidino or piperidino; Re is selected from the group consisting of H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, aryl, and (C1-C4)alkanoyl, wherein any (C1-C4)alkyl, (C3-C8)cycloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, and (C1-C4)alkanoyl is optionally substituted with one or more groups independently selected from halo and aryl, and wherein any aryl is optionally substituted with one or more groups independently selected from halo deuterium, nitro, cyano, hydroxy, carboxy, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, and (C1-C4)alkanoyloxy; and each Rx is (C1-C4)alkyl that is substituted with one or more (e.g. 1, 2, 3, or 4) groups independently selected from oxo, carboxy, (C1-C4)alkoxycarbonyl, and amino; or a salt thereof. |
