摘要 |
Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R<SUB>1</SUB>, R<SUB>1</SUB>', R<SUB>1</SUB>'', R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, and R<SUB>6</SUB>, X<SUB>1 </SUB>and X<SUB>2</SUB>, Y, Z, Z<SUB>1</SUB>, Z<SUB>2</SUB>, Z<SUB>3</SUB>, and Z<SUB>4 </SUB>may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.
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