TREATMENT OF CANCERS CHARACTERIZED BY CHROMOSOMAL REARRANGEMENT OF THE NUT GENE
摘要
The present invention is directed, inter alia, to methods of treating NUT midline carcinoma (NMC) by administering compounds that promote increased histone acetylation. The invention also includes assay methods for determining the responsiveness of NMC to specific histone deacetylases and other compounds.
申请公布号
WO2010011700(A2)
申请公布日期
2010.01.28
申请号
WO2009US51328
申请日期
2009.07.21
申请人
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE, INC.;FRENCH, CHRISTOPHER;ASTER, JON;HOFER, MATTHIAS;BRADNER, JAMES
发明人
FRENCH, CHRISTOPHER;ASTER, JON;HOFER, MATTHIAS;BRADNER, JAMES
