摘要 |
This invention relates to novel compounds of the Formula (I), (Ia1-10), (Ib1-10), (Ic1-10), (Id1-7), (Ie1-5) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell. |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.;HIMMELSBACH, FRANK;ECKHARDT, MATTHIAS;HAMILTON, BRADFORD, S.;SCHULER-METZ, ANNETTE;ZHUANG, LINGHANG |
发明人 |
HIMMELSBACH, FRANK;ECKHARDT, MATTHIAS;HAMILTON, BRADFORD, S.;SCHULER-METZ, ANNETTE;ZHUANG, LINGHANG |