FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
摘要
Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain.
申请公布号
WO2009134714(A3)
申请公布日期
2010.01.28
申请号
WO2009US41796
申请日期
2009.04.27
申请人
PRECISION BIOSCIENCES, INC.;NICHOLSON, MICHAEL, G.;JANTZ, DEREK;SMITH, JAMES, JEFFERSON
发明人
NICHOLSON, MICHAEL, G.;JANTZ, DEREK;SMITH, JAMES, JEFFERSON