Prion Protein as a Receptor for Amyloid-Beta Oligomers

摘要

The invention provides methods of inhibiting suppression of long term potentiation, improving acute memory retention and spatial memory performance and treating Alzheimer's disease by administration of a PrPc antagonist or combinations thereof. Additionally, this invention provides pharmaceutical kits comprising, and methods for making and using, such combinations, as well as methods of identifying molecules that could function as PrPc antagonists.

主权项

1. A method comprising administering a therapeutically effective amount of a PrPc antagonist to a subject having Alzheimer's disease (AD), wherein said PrPc antagonist comprises an anti-PrPc antibody, or antigen-binding fragment thereof, which specifically binds to an epitope within amino acids 95 to 110 of SEQ ID NOs:2, 4, or 6.