主权项 |
1. A rapamycin analogue of formula (I) or a pharmaceutically acceptable salt thereof. wherein: R1 represents Me or H; R2 and R3 represent H or R2 and R3 taken together represent keto; X1 and X2 are connected by a moiety selected from: or X2 is connected as follows: and X1 is H; or X1 represents H and X2 represents Z; Ra is selected from H, OH and OMe; Z represents Y represents methylene or is absent; M is selected from bond, CH2, CHMe, CHF, CHOH, CH2CH2CH(OMe), CMe2, CHEt and CF2; Q is selected from bond, CH2, CHMe, CHF, CHOH, CH2CH2, 0, S, CHCH2OH, C(OH)Me and CH(OMe); provided that: (i) when Q is not O or S then one of M or Q must represent CHOH CHCH2OH or C(OH)Me; and (ii) if Q is O or S, then M does not represent CHF, CF2, CHOMe, CHOH; and (iii) M and Q do not both represent bond; either R4 represents CH2OH and R5 represents H or R4 represents H and R5 represents CH2OH; and either R6 represents OH, R7 represents NH2 or H and X represents CH; or R6 represents H, R7 represents H and X represents N. |