发明名称 |
PROTEASE RESISTANT MMUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE |
摘要 |
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair. |
申请公布号 |
AU2016216675(A1) |
申请公布日期 |
2016.09.08 |
申请号 |
AU20160216675 |
申请日期 |
2016.08.18 |
申请人 |
THE BRIGHAM AND WOMEN'S HOPISTAL, INC. |
发明人 |
LEE, RICHARD;SEGERS, VINCENT |
分类号 |
C07K16/00;A61K38/00;A61K38/48;A61P43/00;C07H21/04;C12N9/50 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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