COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS

摘要

The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as antipathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.

主权项

1. A method of treating an autoimmune disorder in a subject in need thereof comprising administering to the subject a nanoparticle complex comprising antigen-MHC complexes operatively coupled to a non-liposomal nanoparticle core in an amount sufficient to expand anti-pathogenic autoreactive T cells; wherein the non-liposomal nanoparticle core has a diameter of less than 1 μm; and wherein the ratio of antigen-MHC complexes operatively coupled to the non-liposomal nanoparticle core is from about 10:1 to about 1000:1.