AUTOCLAVABLE SUSPENSIONS OF CYCLOSPORIN A FORM 2

摘要

Disclosed herein are autoclavable formulations of cyclosporin A Form 2, methods of making such formulations, and methods of treating diseases of the eye with such formulations.

主权项

1. A method of making a formulation of cyclosporin A, the method comprising the steps of
a) dissolving cyclosporin A form 2 in solution; b) autoclaving the solution; c) adding a vehicle selected from carboxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hyaluronic acid, polyvinylpyrrolidone, Carbopol Ultrez 10NF, and Pluronic F127.