NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES

摘要

The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present invention also provides methods of preparing such compounds and compositions, and methods of using the same.

主权项

1. A compound of Formula I:or pharmaceutically acceptable salt, solvate, analog, prodrug, isomer or tautomer thereof wherein:
X1 and X2 are independently selected from O, NR1, or CR1R2; wherein, R1 and R2 are independently selected from H, halogen, substituted or unsubstituted C1-C8 alkyl and heteroalkyl, substituted or unsubstituted C3-C6 cycloalkyl and heterocycloalkyl; and R1 and R2 can be joined to form a ring; Y1, Y2, and Y3 are independently selected from N, CH, or CR1; R3 is Ar orwherein La is CH2, O, NH, or S; Ar is a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl;
R4 and R5 are independently selected from H, substituted or unsubstituted C1-C8 alkyl; and G iswhere
(a) R7 and R8 are H; R6 is H, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 heteroalkyl, C1-C8 alkylaminoalkyl, C1-C8 hydroxyalkylaminoalkyl, C1-C8 alkoxyalkylaminoalkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C1-C8 alkyl C3-C6 cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted C2-C8 heterocycloalkyl, substituted or unsubstituted heteroaryl, C1-C4 alkyl, C1-C4 alkyl, C1-C8 alkylethers, C1-C8 alkylamides, or C1-C4 alkyl;(b) R6 and R8 are H; R7 is H, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 heteroalkyl, C1-C8 alkylaminoalkyl, C1-C8 hydroxyalkylaminoalkyl, C1-C8 alkoxyalkylaminoalkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C1-C8 alkyl C3-C6 cycloalkyl,substituted or unsubstituted aryl, substituted or unsubstituted C2-C8 heterocycloalkyl, substituted or unsubstituted heteroaryl, C1-C4 alkyl, C1-C4 alkyl, C1-C8 alkylethers, C1-C8 alkylamides, or C1-C4 alkyl; or(c) R7 and R8 taken together form a bond; R6 is substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 heteroalkyl, C1-C8 alkylaminoalkyl, C1-C8 hydroxyalkylaminoalkyl, C1-C8 alkoxyalkylammoalkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C1-C8 alkyl C3-C6 cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted C2-C8 heterocycloalkyl, substituted or unsubstituted heteroaryl, C1-C4 alkyl, C1-C4 alkyl, C1-C8 alkylethers, C1-C8 alkylamides, or C1-C4 alkyl.