发明名称 |
PROCESS FOR THE PREPARATION OF CASTANOSPERMINE |
摘要 |
<p>Castanospermine is prepared by starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene-.alpha.-D-glucuronolactone. Two additional carbons are added to the starting material using ethyl acetate and a strong base and the resulting cyclic hemiketal is subjected to a series of reductions, with intervening removal of protecting groups, to give the castanospermine. A substituted hydroxypyrrolidinone and a substituted hydroxypyrrolidine serve as intermediates in the process.</p> |
申请公布号 |
CA2037608(C) |
申请公布日期 |
2000.11.21 |
申请号 |
CA19912037608 |
申请日期 |
1991.03.06 |
申请人 |
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发明人 |
ANZEVENO, PETER B.;ANGELL, PAUL T.;CREEMER, LAURA J. |
分类号 |
C07D471/04;C07D493/04;C07D493/14;(IPC1-7):C07D471/04;C07H9/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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