TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS

摘要

This invention provides the compounds of formula (I), or its a pharmaceutically acceptable ester or amide of such compound, or a pharmaceutically acceptable salt thereof, wherein X<1> is NH; R<1>, R<2>, R<4> through R<6> and R<7> through R<11 >are all hydrogen; R<3> is hydroxy; X<2> and X<3> are methylene; X<4> is a bond; and X<5> is a carbon atom, and the like. These compounds have ORLI -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.