Antibody-containing solutions in which the formation of degradation products and insoluble particles during storage and freeze/thaw cycles is inhibited by adding a sugar and surfactant respectively

摘要

An antibody-containing solution formulation including a nonreducing disaccharide or trisaccharide sugar as a stabilizer. The solution formulation is prepared without including any freeze-drying steps. The antibody is an anti-interleukin-6 receptor antibody or anti-HM1.24 antibody which it a chimeric, humanized or human antibody. Another stabilizer disclosed is a non-ionic surfactant.