发明名称 PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE
摘要 Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X- CH2CH2-Y of formula 7, wherein X is a leaving group and Y is the -(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.
申请公布号 WO2016108172(A1) 申请公布日期 2016.07.07
申请号 WO2015IB60007 申请日期 2015.12.28
申请人 OLON S.P.A. 发明人 CRISTIANO, TANIA;ALPEGIANI, MARCO
分类号 C07C41/16 主分类号 C07C41/16
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