Peptides useful as cell-penetrating peptides

摘要

A peptide having an amino acid sequence containing at least eight consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein. The peptide is suitable as a cell-penetrating peptide. A complex of the peptide and a cargo molecule non-covalently bound to the peptide. The cargo molecule may be a nucleic acid, an amino acid, a peptide, a protein, a carbohydrate, a lipid, or a small molecule. A method of penetrating or transfecting a cell using the complex.

主权项

1. A complex, comprising:
(A) a peptide consisting of SEQ ID NO:3 and which is not-labeled with a radioactive label or a hapten; and (B) a cargo molecule non-covalently bound to the peptide, wherein the non-covalent bond is an ionic bond, a hydrogen bond, or a hydrophobic interaction.