| 摘要 |
Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, E, F, G, I, J, R, R1, R2, R2′, R3, R4, R5, R6, R7, R8, R9 are as described herein. |
| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt or N-oxide thereof, wherein: A, B, D and E are each independently C or N; G and I are selected from the group consisting of C, N, O and S; and R, R1, R2, R3, R4, R5, R6, R7 and R8 are independently H, alkyl, aryl, halo, —O-alkyl, O-aryl, N-alkyl, N,N-dialkyl, N-aryl, N,N-diaryl, cycloalkyl, cycloheteroalkyl or heteroaryl, or R6 and R7 together are oxo and R1-R5, and R8 and R9 are as defined herein or R8 and R9 together are oxo, or R8 and R9 are oxo and R1-R7 are as defined herein or R1-R5 are as defined and R7 and R8 together are oxo; and J is oxo, —H, C1-C6 alkyl, aryl, —OH, cycloalkyl, cycloheteroalkyl or heteroaryl, provided when: the optional double bonds are present, G and I independently are C or N, one of R6, R7 and one of R8, R9 is absent and the others are as defined herein, and J is other than oxo, or is absent or otherwise forming a salt when G is N, or the optional double bond to G is present and the double bond to I is absent, G is C or N, one of R6, R7 is absent and the other is as defined herein, R8 and R9 are as defined herein with one of R8 and R9 absent or otherwise forming a salt when I is N or both are absent when I is O or S or otherwise forming a salt when I is S; and J is other than oxo, or is absent or otherwise forming a salt when G is N, or the optional double bond to I is present and the double bond to G is absent, I is C or N, one of R8, R9 is absent and the other is as defined herein, and forming a salt when I is N; and J is absent when G is O or S or otherwise forming a salt when G is S. |
