| 摘要 |
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition effective in the therapy of cell proliferative disorders such as lung cancer, colon-rectal cancer, rheumatoid arthritis, or other autoimmune diseases.SOLUTION: The invention provides a pharmaceutical composition obtained in combination with thymosin-1-alpha polypeptide and a replication retrovirus vector, the retrovirus vector being a retroviral GAG protein, a retroviral POL protein, a retroviral envelope, or a retroviral polynucleotide, and comprising the polynucleotide comprising a promoter sequence suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain, and an env nucleic acid domain; a cassette comprising an internal ribosome entry site (IRES) operably linked to a heterologous polynucleotide, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope; and cis-acting sequences necessary for reverse transcription, packaging and integration in a target cell.SELECTED DRAWING: Figure 10 |
