CARTILAGE-SPECIFIC EXPRESSION

摘要

The invention provides an isolated nucleic acid comprising a nucleotide sequence for cartilage-specific expression, said sequence comprising the proximal promoter region of the matrilin-1 promoter and at least two cartilage-specific distal control elements capable of binding Sox9 positioned in 5' direction relative to the said proximal promoter region element. Vectors and transgenic animals are also provided.