METHODS AND COMPOSITIONS FOR IMAGING DISORDERS USING POLYSPECIFIC AGENTS

摘要

The present invention provides compositions and methods for detecting and/or monitoring a disease state with polyspecific imaging agents. In a particular embodiment, provided methods may be used to assess efficacy of anti-receptor tyrosine kinase and/or anti-cancer treatments. In some embodiments, the present invention provides methods and compositions relating to polyspecific imaging agents that target neurological, tumor-associated and/or intratumoral markers. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-receptor tyrosine kinase antibodies, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-receptor tyrosine kinase antibodies and/or compositions.

主权项

1. An imaging method comprising
Administering to a subject suffering from or susceptible to a disease a poly-specific imaging agent comprising:
At least a first targeting moiety that interacts specifically with a first target marker;At least a second targeting moiety that interacts specifically with a second target marker different from the first target marker; andAt least one associated detectable moiety, wherein each of the first and second target markers is characterized in that its level of expression or activity is associated with a relevant disease state wherein each of the first and second target markers is characterized by correlation with the same relevant cancer state; and
Detecting the detectable moiety using an imaging modality.